Chronological expression of Wnt target genes CCND1, MYC, CDKN1A, TFRC, PLF1 and Ramp3
S Röhrs, N Kutzner, A Vlad, T Grunwald, S Ziegler… - Cell biology …, 2009 - Elsevier
The canonical Wnt pathway regulates several biological processes including development,
cell growth and proliferation via consecutive gene regulation. A high number of target genes
of the Wnt pathway has been identified, but the chronological order of target gene
expression is still elusive. This order is supposed to be crucial for the controlled course of
events downstream of the activated Wnt pathway. Here we present the expression
chronologies of the target genes Ccnd1 (encoding for cyclin D1), Myc (c-Myc), Cdkn1a …
cell growth and proliferation via consecutive gene regulation. A high number of target genes
of the Wnt pathway has been identified, but the chronological order of target gene
expression is still elusive. This order is supposed to be crucial for the controlled course of
events downstream of the activated Wnt pathway. Here we present the expression
chronologies of the target genes Ccnd1 (encoding for cyclin D1), Myc (c-Myc), Cdkn1a …
